Aaron Hanukoglu, M.D.
Division of Pediatric Endocrinology
Department of Pediatrics
E. Wolfson Medical Center
Tel-Aviv University Sackler Faculty of Medicine
Holon, Israel

Publications of Prof. Aaron Hanukoglu

Reprints of some articles on pseudohypoaldosteronism are available online here.

  1. Hanukoglu, A., Fried, D., and Gotlieb A. Anaphylactic shock due to tetanus toxoid. Harefuah 89, 456-457, 1975.
  2. Josefsberg, Z., Vilunski, E., Hanukoglu, A., Bialik, O., Brown, M., and Laron, Z. Glucose and insulin responses to an oral glucose load in normal children and adolescents in Israel. Israel J. Med. Sci. 12, 189-194, 1976.
  3. Fried, D., and Hanukoglu, A. Fetal transfusion syndrome. British Med. J. 2, 526, 1976.
  4. Gotlieb, A., Fried, D., Hanukoglu, A., Gaizler, K., and Siderer, M. Torsion of spleen in a five and a half months old child. Israel J. Med. Sci. 15, 35-37, 1979.
  5. Hanukoglu, A., Fried, D., and Gotlieb, A. An unusual course of mumps meningoencephalitis. Harefuah 95, 26-27, 1978.
  6. Hanukoglu, A., Fried, D., and Gotlieb, A. Inheritance of pseudohypoaldosteronism. Lancet 1, 1359, 1978.
  7. Hanukoglu, A., Fried, D., and Gotlieb, A. Diphenylhydantoin induced hypersensitivity reaction with an unusual purpuric skin lesion. Eur. J. Pediatr. 134, 177-179, 1980.
  8. Hanukoglu, A., Fried, D., and Hadas, E. Pneumomediastinum and subcutaneous emphysema following foreign body aspiration. Harefuah 98, 262-263, 1980.
  9. Romem, M., Yaniv, I., Hanukoglu, A., Fried, D., and Goodman, R. M. Abetalipoproteinemia - a case report. Metabol. Pediatric Ophtalmol. 5, 29-31, 1981.
  10. Fried, D., Hanukoglu, A., and Birk, O. Leukocyte transfusion in severe neonatal varicella. Acta Pediatr. Scan. 71, 147-149, 1982.
  11. Fried, D., Maytal, Y., and Hanukoglu, A. Differential leukocyte count in shigellosis. Infection 10, 13-15, 1982.
  12. Geva, R., Hanukoglu, A., Sahar, D., and Fried, D. Intracerebral hemorrhage in a full-term infant. Harefuah 102, 19-20, 1982.
  13. Gotlieb, A., Hanukoglu, A., Fried, D., and Rosin, N. Micrognathia associated with asternia and telangiectatic skin lesion. Syndrome Ident. 8, 10-13, 1982.
  14. Somekh, E., Fried, D., Hanukoglu, A., and Raviv, U. Diagnosis of acute interstitial nephritis. Is a kidney biopsy necessary? Pediatrics 65, 505, 1982.
  15. Hanukoglu, A., Bodner, D., and Fried, D. Methemoglobinemia in infants with enteritis. J. Pediatr. 102, 161-162, 1983.
  16. Somekh, E., Fried, D., and Hanukoglu, A. Muscle involvement in Schonlein-Henoch syndrome. Arch. Dis. Child. 58, 929-930, 1983.
  17. Somekh, E., Fried, D., and Hanukoglu, A. Kawasaki Disease. Harefuah 104, 256-258, 1983.
  18. Somekh, E., Fried, D., and Hanukoglu, A. Acute streptococcal interstitial nephritis. Harefuah 105, 316-317, 1983.
  19. Hanukoglu, A., Gutman, R., Fried, D., et al. Lung abscess caused by S. Pneumoniae type 3. Infection 12, 85-87, 1984.
  20. Hanukoglu, A., Somekh, E., and Fried, D. Benign paroxysmal torticollis in infancy. Clin. Pediatr. 23, 272-274, 1984.
  21. Ginot, N., Hanukoglu, A., and Fried, D. Congenital syphilis with negative maternal VDRL in pregnancy. Harefuah 109, 235-237, 1985.
  22. Hanukoglu, A., Shoara, H., Fried, D., et al. Pulmonary involvement in mycoplasma pneumoniae infection in families. Infection. 14, 1-6, 1986.
  23. Hanukoglu, A., Fried, D., and Somekh, E. Inheritance of primary endocardial fibroelastosis. Clin. Pediatr. 25, 272-275, 1986.
  24. Amsel, S. G., Hanukoglu, A., Fried, D., et al. Myocarditis after triple immunization. Arch. Dis. Child. 61, 403-405, 1986.
  25. Hanukoglu, A., Segal, S., and Fried, D. Loss of voice as a sole symptom of subglottic foreign-body aspiration. Am. J. Dis. Child. 140, 973, 1986.
  26. Hanukoglu, A., Meytes, D., Fried, D. et al. Fatal aplastic anemia in a child with Down's syndrome. Acta Paediatr. Scan. 76, 539-543, 1987.
  27. Hanukoglu, A., Chalew, S., and Kowarski, A. A. Late-onset hypocalcemia, rickets, and hypoparathyroidism in an infant of a mother with hyperparathyroidism. J. Pediatr. 112, 751-754, 1988.
  28. Hanukoglu, A., Gonsalves, D., Mizrachi, A. et al. Radiological case of the month: Periappendicular abscess with intraperitoneal gas formation. Am. J. Dis. Child. 142, 889-890, 1988.
  29. Dubey, A. K., Hanukoglu, A., Hansen, B. C., and Kowarski, A. A. Metabolic clearance rates of synthetic human growth hormone in lean and obese male rhesus monkeys. J. Clin. Endocrinol. Metab. 76, 1064-1068, 1988.
  30. Hanukoglu, A., Chalew, S., and Kowarski, A. A. Growth hormone deficiency is not associated with impaired vagal cholinergic nervous system activity in children. Pediatr. Res. 24, 574-576, 1988.
  31. Hansen, B. C., Dubey, A. K., Bodkin, N. L., Hanukoglu, A., and Kowarski, A. A. Increased metabolic clearance rate of growth hormone in obesity parallels increased peripheral insulin resistance and hyperinsulinemia. In: Obesity in Europe I (P. Bjorntrop and S. Rosner, eds.), John Libbey, 1988.
  32. Chalew, S., Udoff, L. C., Hanukoglu, A., Bistritzer, T., Armour, K. M., and Kowarski, A. A. The effect of testosterone therapy on spontaneous growth hormone secretion in boys with constitutional delay. Am. J. Dis. Child. 142, 1345-1348, 1988.
  33. Hanukoglu, A., Chalew, S., Sun, C. C., et al., Surgically curable hypophosphatemic rickets. Clin. Pediatr. 28, 321-325, 1989.
  34. Chalew, S. R. Sakamoto, N., McCarter, R., Hanukoglu, A., Kowarski, A. A. Matjasko, J. Quantitative monitoring of brain function, vital signs and hormonal response during acute insuline induced hypoglycemia. J. Clin. Monitoring 5, 229-235, 1989.
  35. Hanukoglu, A., Chalew, S., Kowarski, A. A. Human pancreatic polypeptide levels in children and young adults. Hormone Metab. Res. 22:41-43, 1990.
  36. Hanukoglu, I., Feuchtwanger, R., Hanukoglu. A. Mechanism of corticotropin and cAMP induction of mitochondrial cytochrome P450 system enzymes in adrenal cortex cells. J. Biol. Chem. 265:20602-20608, 1990.
  37. Bistritzer, T., Chalew, S. A., Hanukoglu, A., Armour, K. M., P. Haney, J., and A. Kowarski, A. Does growth hormone influence the severity of phoshopenic rickets? Eur. J. Pediatr. 150:26-29, 1990.
  38. Hanukoglu, A. Type I pseudohypoaldosteronism includes two clinically and genetically distinct entities with either renal or multiple target organ defects. J. Clin. Endocrinol. Metab. 73:936-944, 1991.
  39. Hanukoglu, A., Gewurtz, G., Zaidel, L., Krispin, M., and Fried, D. Benign cystic mesothelioma of infancy: The occurrence of an adulthood entity in a child. Med. Ped. Oncology. 20:169-71, 1992.
  40. Ulick, S., Wang J. Z., Hanukoglu, A., Rosler, A. The effect of carbenoxolone on the peripheral metabolism of cortisol in man. J. Lab. Clin. Med. 122: 673-676, 1993.
  41. Stein, D., Hanukoglu, A., Blank, S., Elizur, A. Cyclic psychosis associated with the menstrual cycle. case report Brit. J. Psychiat. 163: 824-828, 1993.
  42. Hanukoglu, A., Somekh E. Infectious mononucleosis-like illness in an infant with acute herpesvirus 6 infection. Pediatr. Infect. Dis. J. 13: 750-751, 1994.
  43. Hanukoglu, A., Bistritzer, T., Rakover, Y., and Mandelberg A. Pseudohypoaldosteronism with increased sweat and saliva electrolyte values and frequent lower respiratory tract infections mimicking cystic fibrosis. J. Pediatr. 125:752-755, 1994.
  44. Hanukoglu, A., Danielli, L., Katzir, Z., Gorenstein, A., Fried, D. Serious complications of routine ritual circumcision in a neonate: hydro-ureteronephrosis, amputation of glans penis and hyponatremia. Eur. J. Pediatr 154:314-16, 1995.
  45. Hanukoglu A., Fried, D., and Hanukoglu I. Selective increases in adrenal steroidogenic capacity during acute illness in infants. Eur. J. Endocrinol. 133:552-556, 1995.
  46. Chung E., Hanukoglu A., Rees M., Thompson R., Dillon M., Hanukoglu I., Bistritzer T., Kuhnle U., Seckl J., and Gardiner R.M. Exclusion of the locus for autosomal recessive Pseudohypoaldosteronism type 1 from the mineralocorticoid receptor gene region on human chromosome 4q by linkage analysis. J. Clin. Endocrinol. Metab. 80, 3341-3345, 1995.
  47. Strautnieks, S.S., Thompson, R.J., Hanukoglu, A., Dillon, M.J. Hanukoglu, I., Kuhnle, U., Seckl, J. Gardiner, R.M., Chung, E. Localisation of pseudohypoaldosteronism genes to chromosome 16p12.2-13.11 and 12p13.1-pter by homozygosity mapping. Hum. Mol. Genetics 5:293-299, 1996.
  48. Chang, S.S., Grunder, S., Hanukoglu, A., Rosler, A., Mathew, P.M., Hanukoglu, I., Schild, L., Lu, Y., Shimkets, R.A., Williams, C.N., Rossier, B.C., Lifton, R.P. Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalemic acidosis, pseudohypoaldosteronism type 1. Nature Genetics 12: 248-253, 1996.
  49. Hanukoglu, A., and Danon, P.N. Endogenous methemoglobinemia associated with diarrheal disease in infancy. J. Pediatr. Gastroenter. Nutr. 23:1-7, 1996.
  50. Bistritzer, T., Lahat, E., Eshel, G., Barr, J., Hanukoglu, A., and Aladjem, M. Severe pseudohypoaldosteronism in a pair of twins not associated with hydramnios. Pediatr. Nephrol. 10:438-441, 1996.
  51. Hanukoglu, A., Joy, O., Steinitz, M., Rosler, A., and Hanukoglu, I. Pseudohypoaldosteronism due to renal and multisystem resistance to mineralocorticoids respond differently to carbenoxolone. J. Steroid Biochem. Molec. Biol. 60:105-112, 1997.
  52. Saxena, A., Hanukoglu, I., Strautnieks, S. S., Thompson, R. J., Gardiner, R. M., and Hanukoglu, A. Gene structure of the human amiloride-sensitive epithelial sodium channel beta subunit. Biochem. Biophys. Res. Commun. 252:208-213, 1998.
  53. Kerem, E., Bistritzer, T., Hanukoglu, A., Hofmann, T., Zhou, Z., Bennett, W., MacLaughlin, E., Barker, P., Nash, M., Quittell, L., Boucher, R., Knowles, MR. Pulmonary epithelial sodium-channel dysfunction and excess airway liquid in pseudohypoaldosteronism. N. Engl. J. Med. 341:156-162, 1999.
  54. Hanukoglu, A., Saxena, A., Gardiner, R. M., and Hanukoglu, I. Aldosterone unresponsiveness (pseudohypoaldosteronism) results from mutations in epithelial sodium channel subunits. In: Molecular Steroidogenesis (M. Okamoto, Y. Ishimura, H. Nawata, eds.), Universal Academy Press, Tokyo, Japan, pp. 369-370, 2000.
  55. Somekh, E., Dagan, R., and Hanukoglu, A. The effect of endogenous dehydroepiandrosterone sulphate (DHEAS) on antibody response to Hepatitis B vaccine in neonates. Israel Med. Assoc. J. 2:200-203, 2000.
  56. Dalal, I., Levin, A., Somekh, E., Mizrachi, A., and Hanukoglu, A. Chronic urticaria in children: Expanding the "Autoimmune Kaleidoscope". Pediatrics, 106:1139-1141, 2000.
  57. Hanukoglu, A., Perlman, K., Shamis, I., Brnjac, L., Rovet, J. and Daneman, D. Relation of etiology to treatment in children with congenital hypothyroidism. J. Clin. Endocrinol. Metab. 86:186-191, 2001.
  58. Hanukoglu, A., Belutserkovsky, O., and Phillip, M. Growth hormone activates renin-aldosterone system in children with idiopathic short stature and in a pseudohypoaldosteronism patient with a mutation in epithelial sodium channel alpha subunit. J. Steroid Biochem. Molec. Biol. 77:49-57, 2001.
  59. Hanukoglu A., Saxena A., and Hanukoglu I. Aldosterone insensitivity syndromes (pseudohypoaldosteronism): from clinic to molecular biology of sodium transport. Pol. J. Endocrinol. 52 (Suppl. 1):27-37, 2001.
  60. Ottaviani E., Franchini A., Mandrioli M., Saxena A., Hanukoglu A., Hanukoglu I. Amiloride-sensitive epithelial sodium channel (ENaC) subunits are expressed in human and mussel immunocytes. Dev Comp Immunol 26:395-402, 2002.
  61. Saxena A., Hanukoglu I., Saxena D., Thompson R. J., Gardiner R. M., and Hanukoglu A. Novel mutations responsible for autosomal recessive multi-system pseudohypoaldosteronism and sequence variants in epithelial sodium channel (ENaC) alpha, beta and gamma subunit genes. J. Clin. Endocrinol. Metab. 87:3344-3350, 2002.
  62. Hanukoglu A., Mizrachi A., Dalal I., Admoni O., Rakover Y., Bistritzer Z., Levine A., Somekh E., Lehmann D., Tuval M., Boaz M., Golander A. Extrapancreatic autoimmune manifestations in diabetes mellitus type 1 patients and their first-degree relatives. A multi-center study. Diabetes Care 26:1235-1240, 2003.
  63. Somekh E., Cesar K., Handsher R., Hanukoglu A., Dalal I., Ballin A., Shohat T. An outbreak of echovirus 13 meningitis in central Israel. Epidemiol Infect. 130:257-262, 2003.
  64. Zung A., Elizur M., Weintrob N., Bistritzer T., Hanukoglu A., Zadik Z., Phillip M., Miller K., Koren I., Brautbar C., Israel S. Type 1 diabetes in Jewish Ethiopian immigrants in Israel: HLA class II immunogenetics and contribution of new environment. Hum Immunol. 65:1463-1468, 2004.
  65. Edelheit O., Hanukoglu I., Gizewska M., Kandemir N., Tenenbaum-Rakover Y., Yurdakok M., Zajaczek S., Hanukoglu A. Novel mutations in epithelial sodium channel (ENaC) subunit genes and phenotypic expression of multi-system pseudohypoaldosteronism. Clin Endocrinol. 62:547-553, 2005.
  66. Leshinsky-Silver E., Landau Z., Unlubay S., Bistrizer T., Zung A., Tenenbaum-Rakover Y., Devries L., Lev D., Hanukoglu A. Congenital Hyperreninemic Hypoaldosteronism in Israel: Sequence Analysis of CYP11B2 Gene. Horm Res. 66:73-78, 2006.
  67. Landau Z., Wainstein J., Hanukoglu A., Tuval M., Lavie J., Glaser B. Sulfonylurea-responsive diabetes in childhood. J Pediatr. 150:553-555, 2007.
  68. Hanukoglu A., Edelheit O., Shriki Y., Gizewska M., Dascal N., Hanukoglu I. Renin-aldosterone response, urinary Na/K ratio and growth in pseudohypoaldosteronism patients with mutations in epithelial sodium channel (ENaC) subunit genes. J Steroid Biochem Mol Biol 111:268-274, 2008.
  69. Hanukoglu A., Curiel B., Berkowitz D., Levine A., Sack J., Lorberboym M. Hypothyroidism and dyshormonogenesis induced by D-penicillamine in children with Wilson's disease and healthy infants born to a mother with Wilson's disease. J Pediatr. 153:864-866, 2008.
  70. Gazit V, Tasher D, Hanukoglu A, Landau Z, Ben-Yehuda Y, Somekh E, Dalal I.Atopy in children and adolescents with insulin-dependent diabetes mellitus. Isr Med Assoc J. 10:858-61, 2008.
  71. Landau Z., Hanukoglu A., Sack J., Goldstein N., Weintrob N., Eliakim A., Gillis D., Sagi M., Shomrat R., Kosinovsky E.B., Anikster Y. Clinical and genetic heterogeneity of congenital adrenal hypoplasia due to NR0B1 gene mutations. Clin Endocrinol (Oxf). 2009.
  72. Zung A., Tenenbaum-Rakover Y., Barkan S., Hanukoglu A., Hershkovitz E., Pinhas-Hamiel O., Bistritzer T., Zadik Z. Neonatal hyperthyrotropinemia: population characteristics, diagnosis, management and outcome after cessation of therapy. Clin Endocrinol (Oxf). 2009.
  73. Edelheit O., Hanukoglu A., and Hanukoglu I. Simple and efficient site-directed mutagenesis using two single-primer reactions in parallel to generate mutants for protein structure-function studies. BMC Biotechnology 9:61, 2009.
  74. Edelheit O., Hanukoglu I., Shriki Y., Tfilin M., Dascal N., Gillis, D., Hanukoglu A. Truncated beta epithelial sodium channel (ENaC) subunits responsible for multi-system pseudohypoaldosteronism support partial activity of ENaC. J Steroid Biochem Mol Biol , 2010.

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