Israel Hanukoglu, Ph. D.
Department of Molecular Biology
Ariel University Center of Samaria
Ariel 40700, Israel

• Education
• Positions Held
• Awards and Fellowships
• Civic and Administrative Functions
• Functions in International Symposiums
• Invited Symposiums
• Research Associates
• Research Grants
• Research Achievements
• Publications
• Teaching

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Date and Place of Birth: March 14, 1952, Istanbul, Turkey

Family: Married to Sarah Hanukoglu-Leitman.

Education

1966-1969		Ataturk Boys' High School, Istanbul, Turkey.
1969-1970		Joseph A. Craig High School, Janesville, Wisconsin, U.S.A. (Graduation rank: 8th in a class of 459).
1970-1974	B.A.	Hebrew University of Jerusalem, Israel. (Cum laude, Majors: Biology and Psychology).
1975-1976	M.Sc.	University of Wisconsin-Madison, Wisconsin, U.S.A. (Major: Endocrinology-Biochemistry Emphasis. Thesis: Progesterone metabolism in the pineal, brain stem, thalamus and corpus callosum of the female rat. Major Professors: H. J. Karavolas, and R. W. Goy).
1977-1980	Ph.D.	University of Wisconsin-Madison, Wisconsin, U.S.A. (Major: Endocrinology-Biochemistry Emphasis. Thesis: Mechanism of electron transport to cytochrome P-450 in adrenal cortex mitochondrial steroid monooxygenase systems. Major Professors: C. R. Jefcoate and N. L. First).

Positions Held

1975-1980	Research Assistant, Departments of Physiological Chemistry, Pharmacology, and Primate Research Center, University of Wisconsin-Madison.
1980-1983	Research Fellow/Associate, Department of Biochemistry, The University of Chicago.
1984-1986	Lecturer, Department of Biology, Technion-Israel Institute of Technology.
1986-1987	Senior Lecturer, Department of Biology, Technion-Israel Institute of Technology.
1987-1993	Senior Scientist, Department of Hormone Research, Weizmann Institute of Science.
1993-1995	Associate Professor, Department of Hormone Research, Weizmann Institute of Science.
1994-2001	Associate Professor, The Research Institute, The College of Judea and Samaria, Ariel.
1995-1997	Head of the Social and Life Sciences Program, The College of Judea and Samaria.
1995-1996	Associate Professor, Institute of Endocrinology, Sourasky-Tel Aviv Medical Center, Tel-Aviv.
1996-1999	Science Adviser to the Prime Minister of Israel.
1999-	Founder and Editor, Israel Science and Technology Homepage.
2001-2007	Professor of Biochemistry and Molecular Biology, The College of Judea and Samaria, Ariel.
2003-2008	Founder and Chairman, Department of Molecular Biology, Ariel University Center.
2007-	Professor of Biochemistry and Molecular Biology, Ariel University Center.

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Awards and Fellowships

1969-1970	American Field Service (AFS) International Scholarship.
1971-1973	Undergraduate Class Representative, B. A. degree cum laude (In a class of 516, only top 27 students cum laude).
1975	Ford Foundation Fellowship in Endocrinology.
1981	Damon Runyon-Walter Winchell Cancer Fund Fellowship Award in Biochemistry.
1982-1983	National Cancer Institute, National Research Service Award for Postdoctoral Fellowship in Biochemistry.
1984	Technion V.P.R. Fund-Henri Gutwirth Award for Excellence in Research.
1987-1993	Delta Research Career Development Award.
1988	The first Hans Lindner Prize in Biochemical Endocrinology, Israel Endocrine Society.
1991	Lubell Prize for outstanding young scientist at the Weizmann Institute of Science.
1993	Best poster abstract award, Israel Endocrine Society.
2009	Best poster presentation award, Israel Endocrine Society.

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Civic and Administrative Functions

1971-1974	Elected Representative of the Psychology students (class of about 120 students).
1984	Advisor for first year students of Biology in Technion.
1985-1987	Representative of the Department of Biology in Computer and Microcomputer Committees in Technion.
1988-1993	Elected Representative of the Senior Scientists in the Scientific Council of the Weizmann Institute of Science (elected in five consecutive terms).
1994-1995	Editor of "The Academic Zionist", newsletter of Professors for a Strong Israel.
1995-1996	Chairman of Professors for a Strong Israel (a non-profit civic organization with about 600 members).
1996-	Founding member of the Executive Committee of The Ariel Center for Policy Research.
1996-1999	Science adviser to the Israeli Prime Minister. In this capacity I represented the Prime Minister's office in the following committees: The Committee of Chief Scientists (of governmental ministries) The National Council for Research and Development Knesset Science and Technology committee The ad hoc Committee of Director Generals (Mankalim) to Advance Science and Technology Education The education sub-committee of the "A computer for every child" project.
2000-2003	Chairman, Computing and Information Technology Committee of the College, followed by charimanship of the Internet Committee.
2003-2005	Scientific Adviser to the Mayor of Rishon-LeZion for establishing the Outdoors Museum and Boulevard for Jewish Nobel Prize Laureates.
2007	Faculty of Natural Sciences, Dean Search Committee Member.
2008	Ariel University Center, Vice President Search Committee Member.

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Functions in International Symposiums

Chairman, The First International Symposium on A Molecular View of Steroid Biosynthesis and Metabolism (supported by a budget of $70,000 by Ares-Serono Symposia), Jerusalem, Israel, October 14-17, 1991.

Vice Chairman, 9th International Symposium on Microsomes and Drug Oxidations, Jerusalem, Israel, July 5-9, 1992.

Program Organizing Committee Member, International Congress of Hormonal Steroids, Dallas, Texas, 1994.

Scientific Committee Member, Eurasian Symposium on Current Trends in Biotechnology: Gene Diagnostics, Gene Therapy, and Informational Immunity, Ankara, Turkey, October 29-November 6, 1995.

Organizing Committee Member, 2nd International Symposium on Molecular Steroidogenesis, Monterey, California, June 7-11, 1996.

Program Organizing Committee Member, The 10th International Congress on Hormonal Steroids, Quebec City, Montreal Canada, June 17-21, 1998.

International Scientific Committee Member, The Third International Symposium on Molecular Steroidogenesis, Nara, Japan August 25-28, 1999.

International Scientific Committee Member, The 4th International Symposium on Molecular Steroidogenesis, Bath, England, April 24-27, 2003.

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Invited Symposiums and Meetings

American Society of Biological Chemists Annual Meeting Minisymposium on Cytochrome P-450, New Orleans, Louisiana, June 5-8, l980.

The American Society for Cell Biology Annual Meeting Minisymposium on Molecular Biology of Cell Function, San Antonio, Texas, November 29-December 3, 1983.

Evolutionary Processes and Theory, International Workshop-Conference, Jerusalem, March 19-28, 1985.

Follicular Development and the Ovulatory Response, Ares-Serono Symposia, Tiberias, April 10-12, 1989.

NATO Advanced Study Institute on Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds, Izmir, Turkey, August 27-September 7, 1989.

National Biochemistry Congress, Antalya, Turkey, November 19-23, 1989.

Tenth International Symposium on Flavins and Flavoproteins, Como, Italy, July 15-20, 1990 (Travel Award).

15th International Congress of Biochemistry, Jerusalem, Israel, August 4-8, 1991.

7th International Conference on Biochemistry and Biophysics of Cytochrome P-450, Moscow, USSR, July 28-August 2, 1991.

9th International Symposium on Microsomes and Drug Oxidations, Jerusalem, Israel, July 5-9, 1992.

National Biochemistry Congress, Antalya, Turkey, October 24-28, 1992.

8th International Conference on Cytochrome P450 Biochemistry Biophysics and Molecular Biology, Lisbon, Portugal, October 24-29, 1993.

Neuroendocrine Immune Mechanisms in Stress. Stockholm, Sweden, October 25-26, 1993.

XVI Meeting of the International Study Group for Steroid Hormones. Wien, Austria, November 28-30, 1993.

2nd Inserm-Weizmann Conference on Molecular Endocrinology. Rehovot, December 5-10, 1993.

Novel Aspects of membrane mediated cellular responses: the roles of reactive oxygens. Tirol, January 8-11, 1994.

Sixth Conference on the Adrenal Cortex. Ardmore, Oklahoma, U.S.A., September 21-24, 1994.

Eurasian Symposium on Current Trends in Biotechnology: Gene Diagnostics, Gene Therapy, and Informational Immunity. Ankara, Turkey, October 29-November 6, 1995.

2nd International Symposium on Molecular Steroidogenesis. Monterey, California, June 7-11, 1996.

Israeli Endocrine Society Meeting. Jerusalem, Israel, 1996.

The Keio University International Symposia for Life Sciences and Medicine. 1996 Conference on Oxygen Homeostasis and its Dynamics. December 8-13, 1996.

NATO Advanced Study Institute on Molecular and applied aspects of oxidative drug metabolizing enzymes. Antalya, Turkey. August 31-September 11, 1997.

International Symposium on Molecular Steroidogenesis. Nara, Japan. August 25-28, 1999.

International Workshop: From Sequence to Function: Experimental and Bioinformatic Studies of Cytochrome P450 Superfamily. Moscow, Russia. July 6-10, 2000.

4th International Workshop on Molecular Steroidogenesis, Bath, England, April 24-27, 2003.

American Physiological Society Conference on "Aldosterone and ENaC: From Genetics to Physiology". Banff, Alberta, Canada. September 10-14, 2003.

Membership in Professional Societies

1983- American Society for Biochemistry and Molecular Biology
1983- The Endocrine Society (U.S.A.)
1987- Israel Endocrine Society
1989- Israel Biochemical Society

Reviewer for journals and research grant funding agencies

American Journal of Respiratory and Critical Care Medicine
Archives of Biochemistry and Biophysics
Biochimica Biophysica Acta
Bioinformatics
BMC Genetics
DNA and Cell Biology
European Journal of Biochemistry
Journal of Steroid Biochemistry and Molecular Biology
Reproduction
German-Israeli Foundation for Scientific Research and Development
Israel Academy of Sciences Basic Research Fund
Israel Cancer Association
Israel Ministry of Science
Israel Science Foundation
March of Dimes - Birth Defects Foundation
TUBITAK - Science and Technology Research Foundation of Turkey
U.S.-Israel Binational Science Foundation

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Research Grant Support

1982 U.S.P.H.S. National Cancer Institute Research Service Award. Subject: "Characterization of human epidermal keratin genes". Approximately $20,000 per year for a three year period.

1984 U.S.P.H.S. National Institutes of Health Research Grant Award. Subject: "Molecular genetics of steroid hydroxylase systems". Approximately $200,000.

1988-1993 The Leo and Julia Forscheimer Center for Molecular Genetics grant. Subject: "Isolation and characterization of peptide hormone inducible genes in steroidogenic tissues". $15,000.

1991-1993 Israel Cancer Society grant. Subject: "Identification of Trophic Hormone Regulated Proto-oncogenes". $15,000 per year.

1991-1993 Israel Cancer Research Fund grant. Subject: "Trophic hormone regulation of proto-oncogene expression". $18,000 per year.

1991-1993 Godfrey Foundation Grant for Research on Children's Diseases. Subject: "Molecular genetics of pseudohypoaldosteronism". $26,000 per year.

1992-1993 Kimmelman Center for Biomolecular Structure and Assembly. Subject: Expression of cytochrome P450 system electron transport enzymes for crystallographic analysis".

1992 Joseph Cohn Center for Biomembrane Research. Subject: Characterization of ACTH receptor by molecular cloning". 1992-1994 Israel Academy of Sciences Basic Research Fund grant. Subject "Molecular cloning and characterization of ACTH and MSH receptors". $37,000 per year.

1992-1994 Israel Ministry of Health. Subject: "Pseudohypoaldosteronism: Identification of genetic defects in mineralocorticoid receptor and clinical trial with carbenoxolone." 30,000 N.I.S.

1995-1997 UK-Israel Science and Technology Research Fund. Subject: "Molecular genetic analysis of pseudohypoaldosteronism".

2000-2004 Israel Ministry of Health. Subject: "Characterization of the molecular basis of a salt wasting syndrome (pseudohypoaldosteronism) that results from unresponsiveness to aldosterone".

2008-2011 Israel Ministry of Health. Subject: "Epithelial sodium channels (ENaC): Structure-function relationships and the effect of mutations that cause Pseudohypoaldosteronism on the function of the channels." 100,000 N.I.S. per year.

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Teaching

Courses taught in the past:

• Biological Membranes and Bioenergetics" for biology students.
• Molecular Biology for biology students.
• Biochemistry for medical students.
• Microcomputers in Biochemistry for graduate students.
• Molecular biology of steroid hormone synthesis and action for graduate students.
• Internet information systems and applications for engineering students.
• Seminar on advanced topics in biochemistry for biology students.

Currently teaching in the Ariel University Center of Samaria:

• Introduction to Biochemistry for biology students.
• Introduction to Computing in Natural Sciences.
• Molecular Biology and Genetics for chemical engineering and biotechnology majors.
• Information Systems and Applications in Bioinformatics for second year biology majors.
• Biochemistry and Molecular Biology Laboratory for second year students.