Israel Hanukoglu, Ph. D.
Department of Molecular Biology
Ariel University Center in Samaria
Ariel 44837, Israel

(This is a partial list of publications of Prof. I. Hanukoglu. For other topics select one of the options on the left side menu.)

2. Progesterone metabolism in the pineal, brain stem, thalamus and corpus callosum of the female rat.

Hanukoglu I., Karavolas H.J., and Goy R.W. Brain Res 125:313-324, 1977.
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4. Pregnenolone separation from cholesterol using Sephadex LH-20 minicolumns

Hanukoglu I., and Jefcoate C.R. J Chromatogr 190:256-262, 1980.
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5. Mitochondrial cytochrome P-450scc. Mechanism of electron transport by adrenodoxin.

Hanukoglu I., and Jefcoate C.R. J Biol Chem 255:3057-3061, 1980.
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6. Mechanism of electron transport to cytochrome P-450 in adrenal cortex mitochondrial monooxygenase systems

Hanukoglu I. Ph. D. Dissertation, University of Wisconsin- Madison. , 1980.

7. Adrenal mitochondrial cytochrome P-450scc. Cholesterol and adrenodoxin interactions at equilibrium and during turnover.

Hanukoglu I., Spitsberg V., Bumpus J.A., Dus K.M., and Jefcoate C.R. J Biol Chem 256:4321-4328, 1981.
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8. Mechanisms of ionic activation of adrenal mitochondrial cytochromes P-450scc and P-45011 beta.

Hanukoglu I., Privalle C. T., and Jefcoate C. R. J Biol Chem 256:4329-4335, 1981.
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19. Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum: Implications for membrane organization and gene regulation.

Hanukoglu I., and Hanukoglu Z. Eur J Biochem 157:27-31, 1986.
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20. Isolation of a cDNA for adrenodoxin reductase (ferredoxin-NADP+ reductase). Implications for mitochondrial cytochrome P-450 systems.

Hanukoglu I., Gutfinger T., Haniu M., and Shively J.E. Eur J Biochem 169:449-455, 1987.
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21. Human adrenodoxin reductase: two mRNAs encoded by a single gene on chromosome 17cen-q25 are expressed in steroidogenic tissues.

Solish S. B., Picado-Leonard J., Morel Y., Kuhn R. W., Mohandas T.K., Hanukoglu I., and Miller W.L. Proc Natl Acad Sci U S A 85:7104-7108, 1988.
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22. cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases.

Hanukoglu I., and Gutfinger T. Eur J Biochem 180:479-484, 1989.
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23. Olfactory-specific cytochrome P-450. cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception.

Nef P., Heldman J., Lazard D., Margalit T., Jaye M., Hanukoglu I., and Lancet D. J Biol Chem 264:6780-6785, 1989.
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24. Molecular biology of cytochrome P450 systems in steroidogenic tissues

Hanukoglu I. Serono Symposia Review 23:233-252, 1989.

25. Elimination of non-specific binding in western blots from non-reducing gels.

Hanukoglu I. J Biochem Biophys Methods 21:65-68, 1990.
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26. Induction and mitochondrial localization of cytochrome P450scc system enzymes in normal and transformed ovarian granulosa cells.

Hanukoglu I., Suh B.S., Himmelhoch S., and Amsterdam A. J Cell Biol 111:1373-1381, 1990.
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27. Mechanism of corticotropin and cAMP induction of mitochondrial cytochrome P450 system enzymes in adrenal cortex cells.

Hanukoglu I., Feuchtwanger R., and Hanukoglu A. J Biol Chem 265:20602-20608, 1990.
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28. Adrenodoxin reductase of mitochondrial cytochrome P450 systems: structure and regulation of expression

Hanukoglu I. Flavins and Flavoproteins 1990 (Curti, B., Ronchi, S., and Zanetti, G., Eds.). pp. 859-864, 1991.

29. Rapid preparation of lambda phage DNA

Raikhinstein M., and Hanukoglu I. Meth. Mol. Cell. Biol. 3:108-111, 1992.

30. Reductases of the bacterial, mitochondrial and microsomal cytochrome P450 systems: structural comparisons

Hanukoglu I. Cytochrome P-450: Biochemistry and Biophysics (A.I. Archakov and G.I. Bachmanova, eds.), INCO-TNC, Moscow, pp. 339-344, 1992.

31. Current research on steroid metabolism: transition from biochemistry to molecular-cell biology.

Hanukoglu I. J Steroid Biochem Molec Biol 43:745-749, 1992.
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32. Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis.

Hanukoglu I. J Steroid Biochem Molec Biol 43:779-804, 1992.
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33. Oncogene-transformed granulosa cells as a model system for the study of steroidogenic processes.

Amsterdam A., Hanukoglu I., Suh B.S., Keren-Tal I., Plehn-Dujowich D., Sprengel R., Rennert H., and Strauss III J.F. J Steroid Biochem Molec Biol 43:875-884, 1992.
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34. A molecular view of steroid metabolism

Hanukoglu I. (editor) J Steroid Biochem Molec Biol 43:745-1124, 1992.

35. Proceedings of the 9th International Symposium on Microsomes and Drug Oxidations

Kapitulnik J., and Hanukoglu I. (editors). J Basic Clin Physiol Pharmacol 3:1-309, 1992.

36. Electron leakage from the mitochondrial NADPH-adrenodoxin reductase-adrenodoxin-P450scc (cholesterol side chain cleavage) system.

Hanukoglu I., Rapoport R., Weiner L., and Sklan D. Arch Biochem Biophys 305:489-498, 1993.
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37. Mitochondrial-genome-encoded RNAs: differential regulation by corticotropin in bovine adrenocortical cells.

Raikhinstein M., and Hanukoglu I. Proc Natl Acad Sci U S A 90:10509-10513, 1993.
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39. cDNA cloning and sequence analysis of the bovine adrenocorticotropic hormone (ACTH) receptor.

Raikhinstein M., Zohar M., and Hanukoglu I. Biochim Biophys Acta 1220:329-332, 1994.
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40. A fluorimetric assay for hydrogen peroxide, suitable for NAD(P)H-dependent superoxide generating redox systems.

Rapoport R., Hanukoglu I., and Sklan D. Anal Biochem 218:309-313, 1994.
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41. Cloning of ACTH-regulated genes in the adrenal cortex.

Raikhinstein M., and Hanukoglu I. J Steroid Biochem Mol Biol 49:257-260, 1994.
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42. Electron pathways in adrenal mitochondrial cytochrome P450 systems: Relative rates of leakage and hydroxylation

Rapoport R., Raikhinstein M., Sklan D., and Hanukoglu I. Cytochrome P-450: Biochemistry Biophysics and Molecular Biology (M. C. Lechner, ed.). John Libbey Eurotext, Paris, pp. 357-363, 1994.

43. Electron leakage from the adrenal cortex mitochondrial P450scc and P450c11 systems: NADPH and steroid dependence.

Rapoport R., Sklan D., and Hanukoglu I. Arch Biochem Biophys 317:412-416, 1995.
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44. Routes and regulation of NADPH production in steroidogenic mitochondria.

Hanukoglu I., and Rapoport R. Endocr Res 21:231-241, 1995.
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45. Selective increases in adrenal steroidogenic capacity during acute respiratory disease in infants.

Hanukoglu A., Fried D., Nakash I., and Hanukoglu I. Eur J Endocrinol 133:552-556, 1995.
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47. Tissue- and species-dependent expression of sheep lung microsomal cytochrome P4502B(LgM2).

Arinc E., Hanukoglu I., Sen A., and Adali O. Biochem Mol Biol Int 37:1121-1126, 1995.

52. Electron transfer proteins of cytochrome P450 systems

Hanukoglu I. Adv Mol Cell Biol 14:29-55, 1996.
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54. Antioxidant capacity is correlated with steroidogenic status of the corpus luteum during the bovine estrous cycle.

Rapoport R., Sklan D., Wolfenson D., Shaham-Albalancy A., and Hanukoglu I. Biochim Biophys Acta 1380:133-140, 1998.
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55. In situ localization of ACTH receptor-like mRNA in molluscan and human immunocytes.

Ottaviani E., Franchini A., and Hanukoglu I. Cell Mol Life Sci 54:139-142, 1998.
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57. Structures of mitochondrial P450 system proteins

Hanukoglu I. Molecular and applied aspects of oxidative drug metabolizing enzymes (E. Arinc, E. Hodgeson and J.B. Schenkman, eds.) Plenum Publishing Corp. pp. 41-54, 1999.

58. Chaperone-assisted expression of authentic bovine adrenodoxin reductase in Escherichia coli.

Vonrhein C., Schmidt U., Ziegler G.A., Schweiger S., Hanukoglu I., and Schulz G.E. FEBS Lett 443:167-169, 1999.
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59. The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis.

Ziegler G.A., Vonrhein C., Hanukoglu I., and Schulz G.E. J Mol Biol 289:981-990, 1999.
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60. Structure and function of bovine adrenodoxin reductase

Ziegler G.A., Vonrhein C., Hanukoglu I., and Schulz G.E. Flavins and Flavoproteins (Ghisla S., Kroneck P., Macheroux P., Sund H., eds.), Rudolf Weber, Berlin, pp. 729-736, 1999.

61. Structures of adrenodoxin reductase and adrenodoxin support shuttle mechanism of electron transfer in mitochondrial P450 systems

Ziegler G.A., Vonrhein C., Schulz G.E., and Hanukoglu I. Molecular Steroidogenesis (M. Okamoto, Y. Ishimura, H. Nawata, eds.), Universal Academy Press, Tokyo, Japan, pp. 61-64, 2000.
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66. ACTH induces TIMP-1 expression and inhibits collagenase in adrenal cortex cells.

Reichenstein M., Reich R., LeHoux J.G., and Hanukoglu I. Mol. Cell. Endocrinol. 215:109-114, 2004.
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68. Antioxidant protective mechanisms against reactive oxygen species (ROS) generated by mitochondrial P450 systems in steroidogenic cells (Review).

Hanukoglu I. Drug Metab Rev 38:171-196, 2006.
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Note: References 5 and 7 are the major references for cholesterol side-chain-cleaving cytochrome P450scc in the IUBMB Enzyme Nomenclature