Aaron Hanukoglu, M.D.
Division of Pediatric Endocrinology
Department of Pediatrics
E. Wolfson Medical Center
Tel-Aviv University Sackler Faculty of Medicine
Holon, Israel

Publications of Prof. Aaron Hanukoglu

Reprints of some articles on pseudohypoaldosteronism are available online here.

  1. Hanukoglu A., Fried D., and Gotlieb A. Anaphylactic shock due to tetanus toxoid. Harefuah 89, 456-457, 1975.
  2. Josefsberg Z., Vilunski E., Hanukoglu A., Bialik O., Brown M., and Laron Z. Glucose and insulin responses to an oral glucose load in normal children and adolescents in Israel. Israel J. Med. Sci. 12:189-194, 1976.
  3. Fried D., and Hanukoglu A. Fetal transfusion syndrome. British Med. J. 2:526, 1976.
  4. Gotlieb A., Fried D., Hanukoglu A., Gaizler K., Siderer M. Torsion of spleen in a five and a half months old child. Israel J. Med. Sci. 15:35-37, 1979.
  5. Hanukoglu A., Fried D., Gotlieb A. An unusual course of mumps meningoencephalitis. Harefuah 95:26-27, 1978.
  6. Hanukoglu A., Fried D., Gotlieb A. Inheritance of pseudohypoaldosteronism. Lancet 1, 1359, 1978.
  7. Hanukoglu A., Fried D., Gotlieb A. Diphenylhydantoin induced hypersensitivity reaction with an unusual purpuric skin lesion. Eur. J. Pediatr. 134:177-179, 1980.
  8. Hanukoglu A., Fried D., Hadas E. Pneumomediastinum and subcutaneous emphysema following foreign body aspiration. Harefuah 98:262-263, 1980.
  9. Romem M., Yaniv I., Hanukoglu A., Fried D., Goodman R.M. Abetalipoproteinemia - a case report. Metabol. Pediatric Ophtalmol. 5:29-31, 1981.
  10. Fried D., Hanukoglu A., Birk O. Leukocyte transfusion in severe neonatal varicella. Acta Pediatr. Scan. 71:147-149, 1982.
  11. Fried D., Maytal Y., Hanukoglu A. Differential leukocyte count in shigellosis. Infection 10:13-15, 1982.
  12. Geva R., Hanukoglu A., Sahar D., Fried D. Intracerebral hemorrhage in a full-term infant. Harefuah 102:19-20, 1982.
  13. Gotlieb A., Hanukoglu A., Fried D., Rosin, N. Micrognathia associated with asternia and telangiectatic skin lesion. Syndrome Ident. 8:10-13, 1982.
  14. Somekh E., Fried D., Hanukoglu A., Raviv U. Diagnosis of acute interstitial nephritis. Is a kidney biopsy necessary? Pediatrics 65:505, 1982.
  15. Hanukoglu A., Bodner D., Fried D. Methemoglobinemia in infants with enteritis. J. Pediatr. 102:161-162, 1983.
  16. Somekh E., Fried D., Hanukoglu A. Muscle involvement in Schonlein-Henoch syndrome. Arch. Dis. Child. 58:929-930, 1983.
  17. Somekh E., Fried D., Hanukoglu A. Kawasaki Disease. Harefuah 104:256-258, 1983.
  18. Somekh E., Fried D., Hanukoglu A. Acute streptococcal interstitial nephritis. Harefuah 105:316-317, 1983.
  19. Hanukoglu A., Gutman R., Fried D., et al. Lung abscess caused by S. Pneumoniae type 3. Infection 12:85-87, 1984.
  20. Hanukoglu A., Somekh E. Fried D. Benign paroxysmal torticollis in infancy. Clin. Pediatr. 23:272-274, 1984.
  21. Ginot N., Hanukoglu A., Fried D. Congenital syphilis with negative maternal VDRL in pregnancy. Harefuah 109:235-237, 1985.
  22. Hanukoglu A., Shoara H., Fried D., et al. Pulmonary involvement in mycoplasma pneumoniae infection in families. Infection. 14:1-6, 1986.
  23. Hanukoglu A., Fried D., Somekh E. Inheritance of primary endocardial fibroelastosis. Clin. Pediatr. 25:272-275, 1986.
  24. Amsel S.G., Hanukoglu A., Fried D., et al. Myocarditis after triple immunization. Arch. Dis. Child. 61:403-405, 1986.
  25. Hanukoglu A., Segal S., Fried D. Loss of voice as a sole symptom of subglottic foreign-body aspiration. Am. J. Dis. Child. 140:973, 1986.
  26. Hanukoglu A., Meytes D., Fried D. et al. Fatal aplastic anemia in a child with Down's syndrome. Acta Paediatr. Scan. 76:539-543, 1987.
  27. Hanukoglu A., Chalew S., Kowarski A.A. Late-onset hypocalcemia, rickets, and hypoparathyroidism in an infant of a mother with hyperparathyroidism. J. Pediatr. 112:751-754, 1988.
  28. Hanukoglu A., Gonsalves D., Mizrachi A. et al. Radiological case of the month: Periappendicular abscess with intraperitoneal gas formation. Am. J. Dis. Child. 142:889-890, 1988.
  29. Dubey A.K., Hanukoglu A., Hansen B.C., Kowarski A.A. Metabolic clearance rates of synthetic human growth hormone in lean and obese male rhesus monkeys. J. Clin. Endocrinol. Metab. 76:1064-1068, 1988.
  30. Hanukoglu A., Chalew S., Kowarski, A.A. Growth hormone deficiency is not associated with impaired vagal cholinergic nervous system activity in children. Pediatr. Res. 24:574-576, 1988.
  31. Hansen B.C., Dubey A.K., Bodkin N.L., Hanukoglu A., Kowarski, A.A. Increased metabolic clearance rate of growth hormone in obesity parallels increased peripheral insulin resistance and hyperinsulinemia. In: Obesity in Europe I (P. Bjorntrop and S. Rosner, eds.), John Libbey, 1988.
  32. Chalew S., Udoff L.C., Hanukoglu A., Bistritzer T., Armour K.M., Kowarski, A.A. The effect of testosterone therapy on spontaneous growth hormone secretion in boys with constitutional delay. Am. J. Dis. Child. 142:1345-1348, 1988.
  33. Hanukoglu A., Chalew S., Sun C.C., et al., Surgically curable hypophosphatemic rickets. Clin. Pediatr. 28:321-325, 1989.
  34. Chalew S.R., Sakamoto N., McCarter R., Hanukoglu A., Kowarski A.A. Matjasko J. Quantitative monitoring of brain function, vital signs and hormonal response during acute insulin induced hypoglycemia. J. Clin. Monitoring 5:229-235, 1989.
  35. Hanukoglu A., Chalew S., Kowarski A.A. Human pancreatic polypeptide levels in children and young adults. Hormone Metab. Res. 22:41-43, 1990.
  36. Hanukoglu I., Feuchtwanger R., Hanukoglu. A. Mechanism of corticotropin and cAMP induction of mitochondrial cytochrome P450 system enzymes in adrenal cortex cells. J. Biol. Chem. 265:20602-20608, 1990.
  37. Bistritzer T., Chalew S.A., Hanukoglu A., Armour K.M., P. Haney, J., Kowarski A.A. Does growth hormone influence the severity of phoshopenic rickets? Eur. J. Pediatr. 150:26-29, 1990.
  38. Hanukoglu A. Type I pseudohypoaldosteronism includes two clinically and genetically distinct entities with either renal or multiple target organ defects. J. Clin. Endocrinol. Metab. 73:936-944, 1991.
  39. Hanukoglu A., Gewurtz G., Zaidel L., Krispin M., Fried D. Benign cystic mesothelioma of infancy: The occurrence of an adulthood entity in a child. Med. Ped. Oncology. 20:169-71, 1992.
  40. Ulick S., Wang J. Z., Hanukoglu A., Rosler A. The effect of carbenoxolone on the peripheral metabolism of cortisol in man. J. Lab. Clin. Med. 122: 673-676, 1993.
  41. Stein D., Hanukoglu A., Blank S., Elizur A. Cyclic psychosis associated with the menstrual cycle. case report Brit. J. Psychiat. 163: 824-828, 1993.
  42. Hanukoglu A., Somekh E. Infectious mononucleosis-like illness in an infant with acute herpesvirus 6 infection. Pediatr. Infect. Dis. J. 13: 750-751, 1994.
  43. Hanukoglu A., Bistritzer T., Rakover Y., Mandelberg A. Pseudohypoaldosteronism with increased sweat and saliva electrolyte values and frequent lower respiratory tract infections mimicking cystic fibrosis. J. Pediatr. 125:752-755, 1994.
  44. Hanukoglu A., Danielli L., Katzir Z., Gorenstein A., Fried D. Serious complications of routine ritual circumcision in a neonate: hydro-ureteronephrosis, amputation of glans penis and hyponatremia. Eur. J. Pediatr 154:314-16, 1995.
  45. Hanukoglu A., Fried D., and Hanukoglu I. Selective increases in adrenal steroidogenic capacity during acute illness in infants. Eur. J. Endocrinol. 133:552-556, 1995.
  46. Chung E., Hanukoglu A., Rees M., Thompson R., Dillon M., Hanukoglu I., Bistritzer T., Kuhnle U., Seckl J., and Gardiner R.M. Exclusion of the locus for autosomal recessive Pseudohypoaldosteronism type 1 from the mineralocorticoid receptor gene region on human chromosome 4q by linkage analysis. J. Clin. Endocrinol. Metab. 80:3341-3345, 1995.
  47. Strautnieks S.S., Thompson R.J., Hanukoglu A., Dillon M.J. Hanukoglu I., Kuhnle U., Seckl J. Gardiner R.M., Chung E. Localisation of pseudohypoaldosteronism genes to chromosome 16p12.2-13.11 and 12p13.1-pter by homozygosity mapping. Hum. Mol. Genetics 5:293-299, 1996.
  48. Chang S.S., Grunder S., Hanukoglu A., Rosler A., Mathew P.M., Hanukoglu I., Schild L., Lu Y., Shimkets R.A., Williams C.N., Rossier B.C., Lifton R.P. Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalemic acidosis, pseudohypoaldosteronism type 1. Nature Genetics 12: 248-253, 1996.
  49. Hanukoglu A., Danon, P.N. Endogenous methemoglobinemia associated with diarrheal disease in infancy. J. Pediatr. Gastroenter. Nutr. 23:1-7, 1996.
  50. Bistritzer T., Lahat E., Eshel G., Barr J., Hanukoglu A., and Aladjem M. Severe pseudohypoaldosteronism in a pair of twins not associated with hydramnios. Pediatr. Nephrol. 10:438-441, 1996.
  51. Hanukoglu A., Joy O., Steinitz M., Rosler A., Hanukoglu I. Pseudohypoaldosteronism due to renal and multisystem resistance to mineralocorticoids respond differently to carbenoxolone. J. Steroid Biochem. Molec. Biol. 60:105-112, 1997.
  52. Saxena A., Hanukoglu I., Strautnieks S.S., Thompson R.J., Gardiner R.M., Hanukoglu A. Gene structure of the human amiloride-sensitive epithelial sodium channel beta subunit. Biochem. Biophys. Res. Commun. 252:208-213, 1998.
  53. Kerem E., Bistritzer T., Hanukoglu A., Hofmann T., Zhou Z., Bennett W., MacLaughlin E., Barker P., Nash M., Quittell L., Boucher R., Knowles MR. Pulmonary epithelial sodium-channel dysfunction and excess airway liquid in pseudohypoaldosteronism. N. Engl. J. Med. 341:156-162, 1999.
  54. Hanukoglu A., Saxena A., Gardiner R.M., Hanukoglu I. Aldosterone unresponsiveness (pseudohypoaldosteronism) results from mutations in epithelial sodium channel subunits. In: Molecular Steroidogenesis (M. Okamoto, Y. Ishimura, H. Nawata, eds.), Universal Academy Press, Tokyo, Japan, pp. 369-370, 2000.
  55. Somekh E., Dagan R., and Hanukoglu A. The effect of endogenous dehydroepiandrosterone sulphate (DHEAS) on antibody response to Hepatitis B vaccine in neonates. Israel Med. Assoc. J. 2:200-203, 2000.
  56. Dalal I., Levin A., Somekh E., Mizrachi A., Hanukoglu A. Chronic urticaria in children: Expanding the "Autoimmune Kaleidoscope". Pediatrics 106:1139-1141, 2000.
  57. Hanukoglu A., Perlman K., Shamis I., Brnjac L., Rovet J. and Daneman D. Relation of etiology to treatment in children with congenital hypothyroidism. J. Clin. Endocrinol. Metab. 86:186-191, 2001.
  58. Hanukoglu A., Belutserkovsky O., Phillip M. Growth hormone activates renin-aldosterone system in children with idiopathic short stature and in a pseudohypoaldosteronism patient with a mutation in epithelial sodium channel alpha subunit. J. Steroid Biochem. Molec. Biol. 77:49-57, 2001.
  59. Hanukoglu A., Saxena A., and Hanukoglu I. Aldosterone insensitivity syndromes (pseudohypoaldosteronism): from clinic to molecular biology of sodium transport. Pol. J. Endocrinol. 52 (Suppl. 1):27-37, 2001.
  60. Ottaviani E., Franchini A., Mandrioli M., Saxena A., Hanukoglu A., Hanukoglu I. Amiloride-sensitive epithelial sodium channel (ENaC) subunits are expressed in human and mussel immunocytes. Dev Comp Immunol 26:395-402, 2002.
  61. Saxena A., Hanukoglu I., Saxena D., Thompson R.J., Gardiner R.M., Hanukoglu A. Novel mutations responsible for autosomal recessive multi-system pseudohypoaldosteronism and sequence variants in epithelial sodium channel (ENaC) alpha, beta and gamma subunit genes. J. Clin. Endocrinol. Metab. 87:3344-3350, 2002.
  62. Hanukoglu A., Mizrachi A., Dalal I., Admoni O., Rakover Y., Bistritzer Z., Levine A., Somekh E., Lehmann D., Tuval M., Boaz M., Golander A. Extrapancreatic autoimmune manifestations in diabetes mellitus type 1 patients and their first-degree relatives. A multi-center study. Diabetes Care 26:1235-1240, 2003.
  63. Somekh E., Cesar K., Handsher R., Hanukoglu A., Dalal I., Ballin A., Shohat T. An outbreak of echovirus 13 meningitis in central Israel. Epidemiol Infect. 130:257-262, 2003.
  64. Zung A., Elizur M., Weintrob N., Bistritzer T., Hanukoglu A., Zadik Z., Phillip M., Miller K., Koren I., Brautbar C., Israel S. Type 1 diabetes in Jewish Ethiopian immigrants in Israel: HLA class II immunogenetics and contribution of new environment. Hum Immunol. 65:1463-1468, 2004.
  65. Edelheit O., Hanukoglu I., Gizewska M., Kandemir N., Tenenbaum-Rakover Y., Yurdakok M., Zajaczek S., Hanukoglu A. Novel mutations in epithelial sodium channel (ENaC) subunit genes and phenotypic expression of multi-system pseudohypoaldosteronism. Clin Endocrinol. 62:547-553, 2005.
  66. Leshinsky-Silver E., Landau Z., Unlubay S., Bistrizer T., Zung A., Tenenbaum-Rakover Y., Devries L., Lev D., Hanukoglu A. Congenital Hyperreninemic Hypoaldosteronism in Israel: Sequence Analysis of CYP11B2 Gene. Horm Res. 66:73-78, 2006.
  67. Landau Z., Wainstein J., Hanukoglu A., Tuval M., Lavie J., Glaser B. Sulfonylurea-responsive diabetes in childhood. J Pediatr. 150:553-555, 2007.
  68. Hanukoglu A., Edelheit O., Shriki Y., Gizewska M., Dascal N., Hanukoglu I. Renin-aldosterone response, urinary Na/K ratio and growth in pseudohypoaldosteronism patients with mutations in epithelial sodium channel (ENaC) subunit genes. J Steroid Biochem Mol Biol 111:268-274, 2008.
  69. Hanukoglu A., Curiel B., Berkowitz D., Levine A., Sack J., Lorberboym M. Hypothyroidism and dyshormonogenesis induced by D-penicillamine in children with Wilson's disease and healthy infants born to a mother with Wilson's disease. J Pediatr. 153:864-866, 2008.
  70. Gazit V, Tasher D, Hanukoglu A, Landau Z, Ben-Yehuda Y, Somekh E, Dalal I. Atopy in children and adolescents with insulin-dependent diabetes mellitus. Isr Med Assoc J. 10:858-861, 2008.
  71. Edelheit O., Hanukoglu A., and Hanukoglu I. Simple and efficient site-directed mutagenesis using two single-primer reactions in parallel to generate mutants for protein structure-function studies. BMC Biotechnology 9:61, 2009.
  72. Landau Z., Hanukoglu A., Sack J., Goldstein N., Weintrob N., Eliakim A., Gillis D., Sagi M., Shomrat R., Kosinovsky E.B., Anikster Y. Clinical and genetic heterogeneity of congenital adrenal hypoplasia due to NR0B1 gene mutations. Clin Endocrinol (Oxf). 72:448-454, 2010.
  73. Zung A., Tenenbaum-Rakover Y., Barkan S., Hanukoglu A., Hershkovitz E., Pinhas-Hamiel O., Bistritzer T., Zadik Z. Neonatal hyperthyrotropinemia: population characteristics, diagnosis, management and outcome after cessation of therapy. Clin Endocrinol (Oxf). 72:264-271, 2010.
  74. Edelheit O., Hanukoglu I., Shriki Y., Tfilin M., Dascal N., Gillis, D., Hanukoglu A. Truncated beta epithelial sodium channel (ENaC) subunits responsible for multi-system pseudohypoaldosteronism support partial activity of ENaC. J Steroid Biochem Mol Biol 119:84-88, 2010.
  75. Hanukoglu A., Hanukoglu I. Clinical improvement in patients with autosomal recessive pseudohypoaldosteronism and the necessity for salt supplementation. Clin Exp Nephrol 14:518-519, 2010.
  76. Muhammad E., Leventhal N., Parvari G., Hanukoglu A., Hanukoglu I., Chalifa-Caspi V., Feinstein Y., Weinbrand J., Jacoby H., Manor E., Nagar T., Beck J.C., Sheffield V.C., Hershkovitz E., Parvari R. Autosomal recessive hyponatremia due to isolated salt wasting in sweat associated with a mutation in the active site of Carbonic Anhydrase 12. Hum Genet 129:397-405, 2011.
  77. Edelheit O., Hanukoglu I., Dascal N., Hanukoglu A. Identification of the roles of conserved charged residues in the extracellular domain of epithelial sodium channel (ENaC) subunit by alanine mutagenesis. Am J Physiol Renal Physiol 300:F887-F897, 2011.
  78. Sherry N, Hagopian W, Ludvigsson J, Jain SM, Wahlen J, Ferry RJ Jr, Bode B, Aronoff S, Holland C, Carlin D, King KL, Wilder RL, Pillemer S, Bonvini E, Johnson S, Stein KE, Koenig S, Herold KC, Daifotis AG; Protege Trial Investigators. Teplizumab for treatment of type 1 diabetes (Protege study): 1-year results from a randomised, placebo-controlled trial. Lancet 378:487-497, 2011.
  79. Landau Z, Karplus G, Hanukoglu A, Abiri S, Levy A, Serour F. Laparoscopic sleeve gastrectomy (LSG) in adolescents with morbid obesity. Harefuah 150:765-768, 2011.
  80. Zung A, Blumenfeld O, Shehadeh N, Dally Gottfried O, Tenenbaum Rakover Y, Hershkovitz E, Gillis D, Zangen D, Pinhas-Hamiel O, Hanukoglu A, Rachmiel M, Shalitin S; Israel IDDM Registry Study Group. Increase in the incidence of type 1 diabetes in Israeli children following the Second Lebanon War. Pediatr Diabetes. 13:326-333, 2012.
  81. Enuka Y., Hanukoglu I., Edelheit O., Vaknine H., Hanukoglu A. Epithelial sodium channels (ENaC) are uniformly distributed on motile-cilia in the oviduct and the respiratory airways. Histochem Cell Biol 137:339-353, 2012.
  82. Landau Z, Abiri S, Barzilay T, Hanukoglu A. Lingual thyroid. J Pediatr Endocrinol Metab. 26:1021-1022, 2013.
  83. Sadeh M, Glazer B, Landau Z, Wainstein J, Bezaleli T, Dabby R, Hanukoglu A, Boaz M, Leshinsky-Silver E. Association of the M3151 variant in the transient receptor potential vanilloid receptor-1 (TRPV1) gene with type 1 diabetes in an Ashkenazi Jewish population. Isr Med Assoc J. 15:477-80, 2013.
  84. Blumenfeld O, Dichtiar R, Shohat T; Israel IDDM Registry Study Group (IIRSG). Trends in the incidence of type 1 diabetes among Jews and Arabs in Israel. Pediatr Diabetes. 15:422-7, 2014.
  85. Edelheit O., Ben-Shahar R., Dascal N., Hanukoglu A., Hanukoglu I. Conserved charged residues at the surface and interface of epithelial sodium channel (ENaC) subunits: roles in cell surface expression and Na+ self-inhibition response. FEBS J 281:2097-2111, 2014.
  86. Mayan H, Carmon V, Oleinikov K, London S, Halevy R, Holtzman EJ, Tenenbaum-Rakover Y, Farfel Z, Hanukoglu A. Hypercalciuria in familial hyperkalemia and hypertension with KLHL3 mutations. Nephron. 130:59-65, 2015.
  87. Hanukoglu I., Hanukoglu A. Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases. Gene 579:95-132, 2016.
  88. Hanukoglu I., Boggula V.R., Vaknine H., Sharma S., Kleyman T., Hanukoglu A. Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages. Histochem Cell Biol 147:733-748, 2017.
  89. Kliuk-Ben Bassat O, Carmon V, Hanukoglu A, Ganon L, Massalha E, Holtzman EJ, Farfel Z, Mayan H. Familial Hyperkalemia and Hypertension (FHHt) and KLHL3: Description of a Family with a New Recessive Mutation (S553L) Compared to a Family with a Dominant Mutation, Q309R, with Analysis of Urinary Sodium Chloride Cotransporter. Nephron 137:77-84, 2017.
  90. Sharma S., Hanukoglu A. , Hanukoglu I. Localization of epithelial sodium channel (ENaC) and CFTR in the germinal epithelium of the testis, Sertoli cells, and spermatozoa. J. Mol. Histol. 49:195-208, 2018.
  91. Hanukoglu A., Hanukoglu I. In systemic pseudohypoaldosteronism type 1 skin manifestations are not rare and the disease is not transient. Clin. Endocrinol. 89:240-241, 2018.
  92. Boggula V.R., Hanukoglu I., Sagiv R., Enuka Y., Hanukoglu A. Expression of the epithelial sodium channel (ENaC) in the endometrium – implications for fertility in a patient with pseudohypoaldosteronism. J Steroid Biochem Mol Biol :, 2018