Our laboratory works mostly with molecular biology techniques on the following subjects:
- Protein and enzyme engineering employing techniques of molecular biology. Structure-function analysis of protein and enzyme structure.
- Structure-function relationships in Epithelial Sodium Channels (ENaC) that regulate blood volume and blood-pressure.
- Intracellular trafficking of ENaC subunits in Xenopus oocytes and epithelial cells.
- Molecular genetics of mineralocorticoid hormone unresponsiveness (pseudohypoaldosteronism) caused by mutations in epithelial sodium channel (ENaC) subunit genes.
- Structure-function analysis of mitochondrial cytochrome P450 system electron transport enzymes involved in steroid hormone biosynthesis (steroidogenesis).
For further information please check our list of publications. Reprints of many articles are available online.
Thank you for your interest.
Israel Hanukoglu
Professor of Biochemistry and Molecular Biology
Hanukoglu Lab team (from left to right): Shay Enuka (graduate student in Genetics), Prof. Israel Hanukoglu, Prof. Aaron Hanukoglu (Tel Aviv University and Wolfson Hospital), and Oded Edelheit (graduate student in Genetics).
