Israel Hanukoglu, Ph.D.
Laboratory of Cell Biology
Ariel University
Ariel 40700, Israel

Publications - Full list in chronological order

NOTE: Full text REPRINTS of some recent publications are available below. Scroll down to see the hyperlinks.

87. Expression of the epithelial sodium channel (ENaC) in the endometrium – implications for fertility in a patient with pseudohypoaldosteronism.
Boggula V.R., Hanukoglu I., Sagiv R., Enuka Y., Hanukoglu A.
J Steroid Biochem Mol Biol :, 2018. DOI

86. In systemic pseudohypoaldosteronism type 1 skin manifestations are not rare and the disease is not transient.
Hanukoglu A., Hanukoglu I.
Clin Endocrinol. 89:240-241, 2018. Reprint

85. Localization of epithelial sodium channel (ENaC) and CFTR in the germinal epithelium of the testis, Sertoli cells, and spermatozoa.
Sharma S., Hanukoglu A., Hanukoglu I.
J Mol Histol 49:195-208, 2018. Reprint

84. Conservation of the enzyme-coenzyme interfaces in FAD and NADP binding adrenodoxin reductase - A ubiquitous enzyme.
Hanukoglu I.
J Mol Evol 85:205-218, 2017. Reprint

83. The concise guide to pharmacology: Overview.
Alexander SP, Kelly E, Marrion NV et al.
Br J Pharmacol 174:Suppl. 1: S1-S16, 2017. DOI

82. Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages.
Hanukoglu I., Boggula V.R., Vaknine H., Sharma S., Kleyman T., Hanukoglu A.
Histochem Cell Biol 147:733–748, 2017. Reprint

81. ASIC and ENaC type sodium channels: Conformational states and the structures of the ion selectivity filters.
Hanukoglu I.
FEBS J 284:525-545, 2017. Reprint

80. Gene Wiki Reviews-Raising the quality and accessibility of information about the human genome.
Tsueng G., Good B.M., Ping P., Golemis E., Hanukoglu I., van Wijnen A.J., Su A.I.
Gene 592:235-238, 2016. Reprint

79. Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.
Hanukoglu I., Hanukoglu A.
Gene 579:95-132, 2016. Reprint

78. Proteopedia: Rossmann fold: A beta-alpha-beta fold at dinucleotide binding sites.
Hanukoglu I.
Biochem Mol Biol Edu 43:206-209, 2015. Reprint

77. Conserved charged residues at the surface and interface of epithelial sodium channel (ENaC) subunits: roles in cell surface expression and Na+ self-inhibition response.
Edelheit O., Ben-Shahar R., Dascal N., Hanukoglu A., Hanukoglu I.
FEBS J 281:2097-2111, 2014. Reprint

76. Proteopedia: Coiled-coil structure of keratins.
Hanukoglu I., Ezra L.
Biochem Mol Biol Edu 42:93-94, 2014. Reprint

75. Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways.
Enuka Y., Hanukoglu I., Edelheit O., Vaknine H., Hanukoglu A.
Histochem Cell Biol 137:339-353, 2012. Reprint

74. Identification of the roles of conserved charged residues in the extracellular domain of epithelial sodium channel (ENaC) subunit by alanine mutagenesis.
Edelheit O., Hanukoglu I., Dascal N., Hanukoglu A.
Am J Physiol Renal Physiol 300:F887-F897, 2011. Reprint

73. Autosomal recessive hyponatremia due to isolated salt wasting in sweat associated with a mutation in the active site of Carbonic Anhydrase 12.
Muhammad E., Leventhal N., Parvari G., Hanukoglu A., Hanukoglu I., Chalifa-Caspi V., Feinstein Y., Weinbrand J., Jacoby H., Manor E., Nagar T., Beck J.C., Sheffield V.C., Hershkovitz E., Parvari R.
Hum Genet 129:397-405, 2011. DOI

72. Clinical improvement in patients with autosomal recessive pseudohypoaldosteronism and the necessity for salt supplementation.
Hanukoglu A., Hanukoglu I.
Clin Exp Nephrol 14:518-519, 2010. Reprint

71. Truncated beta epithelial sodium channel (ENaC) subunits responsible for multi-system pseudohypoaldosteronism support partial activity of ENaC.
Edelheit O., Hanukoglu I., Shriki Y., Tfilin M., Dascal N., Gillis, D., Hanukoglu A.
J Steroid Biochem Mol Biol 119:84-88, 2010. Reprint

70. Simple and efficient site-directed mutagenesis using two single-primer reactions in parallel to generate mutants for protein structure-function studies.
Edelheit O., Hanukoglu A., and Hanukoglu I.
BMC Biotechnology 9:61, 2009. Reprint

69. Renin-aldosterone response, urinary Na/K ratio and growth in pseudohypoaldosteronism patients with mutations in epithelial sodium channel (ENaC) subunit genes.
Hanukoglu A., Edelheit O., Shriki Y., Gizewska M., Dascal N., Hanukoglu I.
J Steroid Biochem Mol Biol 111:268-274, 2008. Reprint

68. Antioxidant protective mechanisms against reactive oxygen species (ROS) generated by mitochondrial P450 systems in steroidogenic cells (Review).
Hanukoglu I.
Drug Metab Rev 38:171-196, 2006. Reprint

67. Novel mutations in epithelial sodium channel (ENaC) subunit genes and phenotypic expression of multi-system pseudohypoaldosteronism (Review).
Edelheit O., Hanukoglu I., Gizewska M., Kandemir N., Tenenbaum-Rakover Y., Yurdakok M., Zajaczek S., Hanukoglu A.
Clin Endocrinol. 62:547-553, 2005. Reprint

66. ACTH induces TIMP-1 expression and inhibits collagenase in adrenal cortex cells.
Reichenstein M., Reich R., LeHoux J.G., and Hanukoglu I.
Mol. Cell. Endocrinol. 215:109-114, 2004. Reprint

65. Novel mutations responsible for autosomal recessive multi-system pseudohypoaldosteronism and sequence variants in Epithelial Sodium Channel (ENaC) alpha, beta and gamma subunit genes.
Saxena A., Hanukoglu I., Saxena D., Thompson R. J., Gardiner R.M., and Hanukoglu A.
J Clin Endocrinol Metab 87:3344-3350, 2002. Reprint

64. Amiloride-sensitive epithelial sodium channel (ENaC) subunits are expressed in human and mussel immunocytes.
Ottaviani E., Franchini A., Mandrioli M., Saxena A., Hanukoglu A., Hanukoglu I.
Dev Comp Immunol 26:395-402, 2002. Reprint

63. Aldosterone insensitivity syndromes (pseudohypoaldosteronism): from clinic to molecular biology of sodium transport.
Hanukoglu A., Saxena A., and Hanukoglu I.
Pol J Endocrinol 52 (Suppl. 1):27-37, 2001.

62. Aldosterone unresponsiveness (pseudohypoaldosteronism) results from mutations in epithelial sodium channel subunits [conference].
Hanukoglu A., Saxena A., Gardiner R.M., and Hanukoglu I.
Molecular Steroidogenesis (M. Okamoto, Y. Ishimura, H. Nawata, eds.), Universal Academy Press, Tokyo, Japan, pp. :369-370, 2000.

61. Structures of adrenodoxin reductase and adrenodoxin support shuttle mechanism of electron transfer in mitochondrial P450 systems [conference].
Ziegler G.A., Vonrhein C., Schulz G.E., and Hanukoglu I.
Molecular Steroidogenesis (M. Okamoto, Y. Ishimura, H. Nawata, eds.), Universal Academy Press, Tokyo, Japan, pp. :61-64, 2000. HTML

60. Structure and function of bovine adrenodoxin reductase [conference].
Ziegler G.A., Vonrhein C., Hanukoglu I., and Schulz G.E.
Flavins and Flavoproteins (Ghisla S., Kroneck P., Macheroux P., Sund H., eds.), Rudolf Weber, Berlin, pp. :729-736, 1999.

59. The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis.
Ziegler G.A., Vonrhein C., Hanukoglu I., and Schulz G.E.
J Mol Biol 289:981-990, 1999. Reprint

58. Chaperone-assisted expression of authentic bovine adrenodoxin reductase in Escherichia coli.
Vonrhein C., Schmidt U., Ziegler G.A., Schweiger S., Hanukoglu I., and Schulz G.E.
FEBS Lett 443:167-169, 1999. Reprint

57. Structures of mitochondrial P450 system proteins [conference].
Hanukoglu I.
Molecular and applied aspects of oxidative drug metabolizing enzymes (E. Arinc, E. Hodgeson and J.B. Schenkman, eds.) Plenum Publishing Corp. pp. :41-54, 1999. DOI

56. Gene structure of the human amiloride-sensitive epithelial sodium channel beta subunit.
Saxena A., Hanukoglu I., Strautnieks S.S., Thompson R.J., Gardiner R.M., and Hanukoglu A.
Biochem Biophys Res Commun 252:208-213, 1998. Reprint

55. In situ localization of ACTH receptor-like mRNA in molluscan and human immunocytes.
Ottaviani E., Franchini A., and Hanukoglu I.
Cell Mol Life Sci 54:139-142, 1998. Reprint

54. Antioxidant capacity is correlated with steroidogenic status of the corpus luteum during the bovine estrous cycle.
Rapoport R., Sklan D., Wolfenson D., Shaham-Albalancy A., and Hanukoglu I.
Biochim Biophys Acta 1380:133-140, 1998. Reprint

53. Pseudohypoaldosteronism due to renal and multisystem resistance to mineralocorticoids respond differently to carbenoxolone.
Hanukoglu A., Joy O., Steinitz M., Rosler A., and Hanukoglu I.
J Steroid Biochem Mol Biol 60:105-112, 1997. Reprint

52. Electron transfer proteins of cytochrome P450 systems.
Hanukoglu I.
Adv Mol Cell Biol 14:29-55, 1996. Reprint

51. Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1.
Chang S.S., Grunder S., Hanukoglu A., Rosler A., Mathew P.M., Hanukoglu I., Schild L., Lu Y., Shimkets R.A., Nelson-Williams C., Rossier B.C., and Lifton R.P.
Nat Genet 12:248-253, 1996. Reprint

50. Localisation of pseudohypoaldosteronism genes to chromosome 16p12.2-13.11 and 12p13.1-pter by homozygosity mapping.
Strautnieks S. S., Thompson R. J., Hanukoglu A., Dillon M.J., Hanukoglu I., Kuhnle U., Seckl J., Gardiner R. M., and Chung E.
Hum Mol Genet 5:293-299, 1996. Reprint

49. Bir bilimadaminin 20 yillik ozlemi. (In Turkish). (English: Twenty years longing of a scientist - an autobiographical essay after a visit to Turkey to attend a scientific meeting).
Hanukoglu I.
Populer Bilim (Popular Science) 2:47-49, 1995.

48. Biyokimyadan molekuler hucre biyolojisine (In Turkish).
Hanukoglu I.
Populer Bilim (Popular Science) 2:45-46, 1995.

47. Tissue- and species-dependent expression of sheep lung microsomal cytochrome P4502B(LgM2).
Arinc E., Hanukoglu I., Sen A., and Adali O.
Biochem Mol Biol Int 37:1121-1126, 1995.

46. Exclusion of the locus for autosomal recessive pseudohypoaldosteronism type 1 from the mineralocorticoid receptor gene region on human chromosome 4q by linkage analysis.
Chung E., Hanukoglu A., Rees M., Thompson R., Dillon M., Hanukoglu I., Bistritzer T., Kuhnle U., Seckl J., and Gardiner R.M.
J Clin Endocrinol Metab 80:3341-3345, 1995. Reprint

45. Selective increases in adrenal steroidogenic capacity during acute respiratory disease in infants.
Hanukoglu A., Fried D., Nakash I., and Hanukoglu I.
Eur J Endocrinol 133:552-556, 1995. Reprint

44. Routes and regulation of NADPH production in steroidogenic mitochondria.
Hanukoglu I., and Rapoport R.
Endocr Res 21:231-241, 1995. Reprint

43. Electron leakage from the adrenal cortex mitochondrial P450scc and P450c11 systems: NADPH and steroid dependence.
Rapoport R., Sklan D., and Hanukoglu I.
Arch Biochem Biophys 317:412-416, 1995. Reprint

42. Electron pathways in adrenal mitochondrial cytochrome P450 systems: Relative rates of leakage and hydroxylation [conference].
Rapoport R., Raikhinstein M., Sklan D., and Hanukoglu I.
Cytochrome P-450: Biochemistry Biophysics and Molecular Biology (M. C. Lechner, ed.). John Libbey Eurotext, Paris, pp. :357-363, 1994.

41. Cloning of ACTH-regulated genes in the adrenal cortex.
Raikhinstein M., and Hanukoglu I.
J Steroid Biochem Mol Biol 49:257-260, 1994. Reprint

40. A fluorimetric assay for hydrogen peroxide, suitable for NAD(P)H-dependent superoxide generating redox systems.
Rapoport R., Hanukoglu I., and Sklan D.
Anal Biochem 218:309-313, 1994. Reprint

39. cDNA cloning and sequence analysis of the bovine adrenocorticotropic hormone (ACTH) receptor.
Raikhinstein M., Zohar M., and Hanukoglu I.
Biochim Biophys Acta 1220:329-332, 1994. Reprint

38. Cloning of LL5, a novel protein encoding cDNA from a rat pituitary library.
Levi L., Hanukoglu I., Raikhinstein M., Kohen F., and Koch Y.
Biochim Biophys Acta 1216:342-344, 1993. Reprint

37. Mitochondrial-genome-encoded RNAs: differential regulation by corticotropin in bovine adrenocortical cells.
Raikhinstein M., and Hanukoglu I.
Proc Natl Acad Sci USA 90:10509-10513, 1993. Reprint

36. Electron leakage from the mitochondrial NADPH-adrenodoxin reductase-adrenodoxin-P450scc (cholesterol side chain cleavage) system.
Hanukoglu I., Rapoport R., Weiner L., and Sklan D.
Arch Biochem Biophys 305:489-498, 1993. Reprint

35. Proceedings of the 9th International Symposium on Microsomes and Drug Oxidations.
Kapitulnik J., and Hanukoglu I. (editors).
J Basic Clin Physiol Pharmacol 3:1-309, 1992. Cover

34. A molecular view of steroid metabolism.
Hanukoglu I. (editor)
J Steroid Biochem Molec Biol 43:745-1124, 1992. Cover

33. Oncogene-transformed granulosa cells as a model system for the study of steroidogenic processes.
Amsterdam A., Hanukoglu I., Suh B.S., Keren-Tal I., Plehn-Dujowich D., Sprengel R., Rennert H., and Strauss III J.F.
J Steroid Biochem Molec Biol 43:875-884, 1992. Reprint

32. Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis.
Hanukoglu I.
J Steroid Biochem Molec Biol 43:779-804, 1992. Reprint

31. Current research on steroid metabolism: transition from biochemistry to molecular-cell biology.
Hanukoglu I.
J Steroid Biochem Molec Biol 43:745-749, 1992. Reprint

30. Reductases of the bacterial, mitochondrial and microsomal cytochrome P450 systems: structural comparisons [conference].
Hanukoglu I.
Cytochrome P-450: Biochemistry and Biophysics (A.I. Archakov and G.I. Bachmanova, eds.), INCO-TNC, Moscow, pp. :339-344, 1992.

29. Rapid preparation of lambda phage DNA.
Raikhinstein M., and Hanukoglu I.
Meth. Mol. Cell. Biol. 3:108-111, 1992.

28. Adrenodoxin reductase of mitochondrial cytochrome P450 systems: structure and regulation of expression [conference].
Hanukoglu I.
Flavins and Flavoproteins 1990 (Curti, B., Ronchi, S., and Zanetti, G., Eds.). pp. :859-864, 1991.

27. Mechanism of corticotropin and cAMP induction of mitochondrial cytochrome P450 system enzymes in adrenal cortex cells.
Hanukoglu I., Feuchtwanger R., and Hanukoglu A.
J Biol Chem 265:20602-20608, 1990. Reprint

26. Induction and mitochondrial localization of cytochrome P450scc system enzymes in normal and transformed ovarian granulosa cells.
Hanukoglu I., Suh B.S., Himmelhoch S., and Amsterdam A.
J Cell Biol 111:1373-1381, 1990. Reprint

25. Elimination of non-specific binding in western blots from non-reducing gels.
Hanukoglu I.
J Biochem Biophys Methods 21:65-68, 1990. Reprint

24. Molecular biology of cytochrome P450 systems in steroidogenic tissues [conference].
Hanukoglu I.
Serono Symposia Review 23:233-252, 1989.

23. Olfactory-specific cytochrome P-450. cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception.
Nef P., Heldman J., Lazard D., Margalit T., Jaye M., Hanukoglu I., and Lancet D.
J Biol Chem 264:6780-6785, 1989. Reprint

22. cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases.
Hanukoglu I., and Gutfinger T.
Eur J Biochem 180:479-484, 1989. Reprint

21. Human adrenodoxin reductase: two mRNAs encoded by a single gene on chromosome 17cen-q25 are expressed in steroidogenic tissues.
Solish S. B., Picado-Leonard J., Morel Y., Kuhn R. W., Mohandas T.K., Hanukoglu I., and Miller W.L.
Proc Natl Acad Sci USA 85:7104-7108, 1988. Reprint

20. Isolation of a cDNA for adrenodoxin reductase (ferredoxin-NADP+ reductase). Implications for mitochondrial cytochrome P-450 systems.
Hanukoglu I., Gutfinger T., Haniu M., and Shively J.E.
Eur J Biochem 169:449-455, 1987. Reprint

19. Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum: Implications for membrane organization and gene regulation.
Hanukoglu I., and Hanukoglu Z.
Eur J Biochem 157:27-31, 1986. Reprint

18. Structural diversity and evolution of intermediate filament proteins [book chapter].
Hanukoglu I., and Fuchs E.
Evolutionary Processes and Theory, (Karlin, M., and Nevo, E. eds.), Academic Press, pp. :69-98, 1986. Reprint

17. Epidermal a-keratins: structural diversity and changes during tissue differentiation.
Fuchs E., and Hanukoglu I.
Biology of the Integument vol 2, (Bereiter-Hahn, J., Matoltsy, A. G., and Richards, K. S. eds.) Springer-Verlag, Berlin, pp. :644-665, 1986. Reprint

16. The nature and significance of differential keratin gene expression.
Fuchs E., Hanukoglu I., Marchuk D., Grace M. P., and Kim K.H.
Ann N Y Acad Sci 455:436-450, 1985. Reprint

15. The influence of differential keratin gene expression on the structure and properties of the resulting 8 nm filaments.
Fuchs E., Kim K.H., Hanukoglu I., Marchuk D., Tyner A., and McCrohon S.
Molecular Biology of the Cytoskeleton. Cold Spring Harbor, pp. :381-393, 1984.

13. The evolution and complexity of the genes encoding the cytoskeletal proteins of human epidermal cells.
Fuchs E., Kim K.H., Hanukoglu I., and Tanese N.
Curr Probl Dermatol 11:27-44, 1983. DOI

12. Unraveling the structure of the intermediate filaments.
Fuchs E., and Hanukoglu I.
Cell 34:332-334, 1983. DOI

11. The cDNA sequence of a Type II cytoskeletal keratin reveals constant and variable structural domains among keratins.
Hanukoglu I., and Fuchs E.
Cell 33:915-924, 1983. Reprint

10. Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions.
Hanukoglu I., Tanese N., and Fuchs E.
J Mol Biol 163:673-678, 1983. Reprint

9. The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins.
Hanukoglu I., and Fuchs E.
Cell 31:243-252, 1982. Reprint

8. Mechanisms of ionic activation of adrenal mitochondrial cytochromes P-450scc and P-45011 beta.
Hanukoglu I., Privalle C. T., and Jefcoate C. R.
J Biol Chem 256:4329-4335, 1981. Reprint

7. Adrenal mitochondrial cytochrome P-450scc. Cholesterol and adrenodoxin interactions at equilibrium and during turnover.
Hanukoglu I., Spitsberg V., Bumpus J.A., Dus K.M., and Jefcoate C.R.
J Biol Chem 256:4321-4328, 1981. Reprint

6. Mechanism of electron transport to cytochrome P-450 in adrenal cortex mitochondrial monooxygenase systems.
Hanukoglu I.
Ph. D. Dissertation, University of Wisconsin-Madison :, 1980.

5. Mitochondrial cytochrome P-450scc. Mechanism of electron transport by adrenodoxin.
Hanukoglu I., and Jefcoate C.R.
J Biol Chem 255:3057-3061, 1980. Reprint

4. Pregnenolone separation from cholesterol using Sephadex LH-20 minicolumns.
Hanukoglu I., and Jefcoate C.R.
J Chromatogr 190:256-262, 1980. Reprint

3. Molecular models of anesthetic drug action - variations on a theme [letter].
Hanukoglu I.
Anesthesiology 47:532-534, 1977.

2. Progesterone metabolism in the pineal, brain stem, thalamus and corpus callosum of the female rat.
Hanukoglu I., Karavolas H.J., and Goy R.W.
Brain Res 125:313-324, 1977. Reprint

1. Prostaglandins as first mediators of stress [letter].
Hanukoglu I.
N Engl J Med 296:1414-1414, 1977.

Note: References 5 and 7 are the major references for cholesterol side-chain-cleaving cytochrome P450scc in the IUBMB Enzyme Nomenclature.