Israel Science and Technology Directory

Bio-pharmaceutical company specializing in development of novel drugs for trans-membrane delivery of macromolecules. Aposense developed a universal platform entitled Molecular Nano-Motors (MNMs) for the delivery of genetic drugs, such as siRNA, into cells based on a novel mechanism of action, utilizing membrane electrical forces. SirVir is an Aposense subsidiary in the field of respiratory viral infections.

Registration of pharmaceuticals (drugs, cosmetics, nutritional supplements) and medical devices according to the requirements of the Israeli Ministry of Health. Certified with ISO 9001 standard. Strategic consulting.

Product and process development, GxP, validation, quality control services. Consultancy for pharmaceutical, biotechnology, medical device companies, cosmetics and food industries.

Clinical data managment. Biostatistics. Clinical programing. Medical writing.

Development of universal multi-season / multi-strain, intranasal flu vaccine. Technology utilizes a combination of conserved epitopes derived from the influenza virus possessing strong immunogenic capabilities.

Turnkey design and construction of pharmaceutical and biotechnological (API) plants. HVAC and clean rooms, sterile and aseptic filling and packaging lines, Cleaning-in-place and sterilization-in-place (CIP/SIP). Systems comply with USP and EU standards.

Clinical-stage biotech company, focusing on development of therapeutics for fibrosis-related diseases. Anti-CCL24 proprietary platform, which hinders the function of the soluble chemokine CCL24 as a regulator of major inflammatory and fibrotic pathways in multiple fibrosis-related disorders.

Manufacture of prescription, generic and over the counter (OTC) pharmaceutical products. Analgesic, anti-inflammatory, antibiotic, antihistamine, anti-hypertensive, antidepressant, diuretic drugs. Multi-vitamin supplements. Oral contraceptive.

Ophthalmic, dermatological and skin-care preparations: Genesis Minerals sunscreens, shampoos, body lotions, Anti Acne Package, antiseptic wet tissues, Kamil Blue - Baby Skin Care products.

Solumer - Nanotechnology for drug re-engineering and production of water-soluble compounds. Soluble anti-cancer and anti-infective drugs, including Itraconazole, Azithromycin, Clarithomycin, Taxol, Cannabidiol in water based solutions.

Biomarkers for autoimmune diseases using glycan molecules as probes via proprietary GlycoChip technology. IBD differential diagnosis (Chron's disease vs. Ulcerative colitis). Multiple sclerosis assay.

International consulting firm for healthcare companies, providing end to end services throughout the life cycle of medical products. Planning, writing or reviewing regulatory submissions.

Biopharmaceuticals. Specialty plasma derivatives, specific and general immune globulins produced using proprietary chromatographic separation and purification methods. Anticoagulant heparin and antagonist. Parenteral electrolyte solutions.

Manufacturer of soy lecithin phosphatidylserine for neurological diseases and as dietary supplements for enhancing foods and beverages.

Debrase Gel Dressing (DGD) enzymatic product used for the debridement of burn wounds. DGD dissolves the eschar within 4 hours of treatment providing a fast and safe alternative to surgery or non-surgical methods.

Manufacture, development, production, distribution and marketing of pharmaceuticals (Rx and OTC), special nutritional supplements and medical devices.

Painless microneedle devices for drug delivery and diagnostics. NanoPump - Low-cost, disposable, biocompatible product for controlled release of large molecules, including therapeutic proteins such as insulin, antibodies and vaccines.

Intranasal powder products based on a unique microsphere technology designed for rapid drug delivery, ease of use, non-invasiveness, and safety. Intranasal Epinephrine (NS –002) for severe allergic type 1 reaction. Powder sprayed into the nose and sinuses forms an acidic gel layer that provides mechanical and chemical protection against viruses, Under trial for COVID-19.

Small molecule drug research and development in the field of central nervous system (CNS) disorders. Circadin- prolonged-release melatonin.

Peptide based active pharmaceutical ingredients for the pharmaceutical industry. Calcium regulators, calcitonin, Parathyroid Hormone. Vasopressin analog Desmopressin. Somatostatin. LHRH analogs Leuprolide, Goserelin, Buserelin, Triptorelin.

Novel antibiotic agents for the treatment of infections involving drug-resistant bacteria. Development of methods that allow Antimicrobial Peptides (AMPs) to become druggable peptides. Development of cyclic constructs of the most efficacious AMPs.

Oramed developed a proprietary platform technology that allows for the oral delivery of drugs presently administered only via injection. Flagship product: an oral insulin capsule that has the potential to better the lives of diabetics, allowing type 2 patients to begin insulin therapy earlier without fear of needles.

Design of novel peptide drug candidates by artificial intelligence based on the 3D structure of the target protein. The company designs Linear peptides, Helical peptides, Cyclic peptides with high serum stability and D-PEP – Peptides with D-amino-acids which are less susceptible to proteolytic cleavage.

Manufacturer of a wide range of products including cardiovascular and dermatological pharmaceuticals, antibiotics, Ethical topical pharmaceuticals. Formerly Agis.

GLP-compliant contract research organization (CRO) that provides early-stage discovery, pre-clinical, early-development services for small and medium-size start-ups. In vivo studies conducted in-house laboratory and animal facilities.

Biomaterials, Hyaluronic Acid (HA) and fibrinogen based hydrogels useful for clinical applications. Proprietary growth factors with enhanced selectivity and biological activity. Stem and progenitor cell isolation, expansion and differentiation.

Bulk production of E. coli-derived recombinant human cytokines and growth factors as well as monoclonal anti-cytokine and chemokine antibodies.

Proprietary plant cell culture and bioreactor system for efficient, large-scale production of complex human therapeutic proteins, monoclonal antibodies, Glucocerebrosidase enzyme replacement for Gaucher's Disease and other recombinant proteins.

Manufacturer of Over-the-Counter medicines (OTC), generic drugs, antibiotics, etc. Kalgaron for sore throat relief. Fluconazole and lansoprazole. Drugs for diseases of the digestive tract and treatment of pain.

Development of late clinical-stage, proprietary drugs for the treatment of gastrointestinal diseases. Drugs under development include oral combination therapy for Helicobacter pylori infection, Crohn's disease, acute gastroenteritis and gastritis.

Biodegradable hydrogels for local repair of damaged cartilage and bone. Gelrin for restoration of normal joint function by regenerating hyaline cartilage and void filling matrix for bone regeneration designed to be used in osseous injuries.

Sol-gel nanotechnology for encapsulation of active ingredients in nano size glass (silica) matrices and nanospheres. UV-Pearls safe and inert sunscreen and cosmetics. Acti-Pearls benzoyl peroxide antibacterial acne medication without irritation.

Pharmaceutical company with a wide range of products, from over-the-counter analgesics and vitamins to injectable anti-cancer drugs.

Distributor of diagnostics and laboratory systems, hygiene and food testing biomedical products in Israel.

Late clinical-stage company dedicated to the development and commercialization of a breakthrough therapeutic approach for better and safer treatment of autoimmune and inflammatory ocular diseases.

Global pharmaceutical company specializing in the development, production and marketing of generic and proprietary branded pharmaceuticals and active pharmaceutical ingredients. Copaxone for the treatment of Relapsing- Remitting Multiple Sclerosis.

Over-the-counter pharmaceuticals. Dermatological preparations, creams and ointments. Non-steroidal anti-inflammatory drug (NSAID) analgesics for rheumatology. Some example products: Acnetrim, Betacorten, Fungimon, Celcox, Diatrim, Dentix.

Manufacture of branded generic drugs for cardiovascular medicine, neurology, psychiatry, gastroenterology, and macrolide antibiotics.

Innovative therapies in dermatology. AMZEEQ (minocycline) topical foam for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in adults and pediatric patients. ZILXITM (minocycline) topical foam, a tetracycline-class drug indicated for the treatment of inflammatory lesions of rosacea in adults.

Novel therapeutics to treat life-threatening infectious diseases based on human monoclonal antibodies (hMAbs) and small molecule drugs. Developing anti-HBV and anti-HCV therapeutics.